李伟辉教授,博士,博/硕士生导师,博士后合作导师
E-mail: lwhlbx@gxu.edu.cn
个人简介:
李伟辉,教授,博/硕士生导师,博士后合作导师。2013年12月毕业于华中农业大学微生物学专业,硕博连读,获得博士学位。2014年1月 - 2019年1月,在华中农业大学农业微生物学国家重点实验室从事博士后研究。2019年2月作为高层次人才引进到best365网页版登录工作;亚热带农业生物资源保护与利用国家重点实验室固定成员;广西微生物与酶工程技术研究中心成员。曾获得国家高等学校科学研究优秀成果奖(自然科学二等奖,重要成员),中国博士后科学基金优秀资助者,优秀博士后,湖北省优秀博士学位论文和武汉市第三届自然科学优秀学术论文等奖项与荣誉。中国微生物学会普通微生物专业委员会委员,中国研究型医院学会结核病学专业委员会委员,《基因组学与应用生物学》杂志副主编。国家自然科学基金评审专家,中国博士后科学基金评审专家,国研平台评审专家。取得的科研成果在Nature子刊Nat Commun与Nucleic Acids Res(3篇)等国际著名期刊上发表,代表性成果的论文平均影响因子14.2。作为项目主持人承担国家自然科学基金2项,国家重点研发计划子课题1项,其它省部级课题多项等。
教学和科研成果:
1. 作为重要成员荣获2013年度国家高等学校科学研究优秀成果奖(自然科学),二等奖;
2. 荣获湖北省优秀博士学位论文;
3. 荣获武汉市第三届自然科学优秀学术论文;
4. 获2021年best365网页版登录教学成果奖特等奖(重要成员);
5. 荣获2019-2020年best365网页版登录优秀班主任;
6. 荣获2019-2021年best365网页版登录优秀共产党员。
主持承担的主要科研项目:
1. 国家自然科学基金面上项目,31870036,2019.01~2022.12,61万元,主持;
2. 国家重点研发计划子课题,2020YFA0907200,2020.11~2025.10,138万元,主持;
3. best365网页版登录国家级人才培育项目,2019.01~2021.12,150万元,主持;
4. best365网页版登录人才科研启动项目,2019.01~2021.12,50万元,主持;
5. 国家自然科学基金青年项目,31401108,2015.01~2017.12,24万元,主持;
6. 中国博士后科学基金特别资助,2016T90699,2016.06~2018.06,15万元,主持;
7. 中国博士后科学基金面上项目一等资助,2014M560612,2014.10~2016.10,8万元,主持。
研究方向:
1.细菌第二信使c-di-GMP受体的发现及其功能的研究;
2.病原微生物与药物靶标;
3.微生物感染与宿主免疫。
指导的学生获奖:
1. 所带本科班级荣获2019-2020学年先进班集体;
2. 所带本科班级荣获2019-2020学年五四红旗团支部等荣誉。
代表性论文:
1.Weihui Li#, Tao Cui#, Lihua Hu#, Ziqing Wang, Zongqiang Li and Zheng-Guo He*. Cyclic diguanylate monophosphate directly binds to human siderocalin and inhibits its antibacterial activity. Nature Communications, 2015, 6:8330, DOI: 10.1038/ncomms9330. (IF2020: 14.919)
2.Weihui Li, Lihua Hu, Zhiwei Xie, Hui Xu, Meng Li, Tao Cui and Zheng-Guo He*. Cyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense. Nucleic Acids Research, 2018, 46 (14), 7270-7283. (IF2020: 16.971)
3.Weihui Li, Meng Li, Lihua Hu, Jingpeng Zhu, Zhiwei Xie, Jiarui Chen and Zheng-Guo He*. HpoR, a novel c-di-GMP effective transcription factor, links the second messenger's regulatory function to the mycobacterial antioxidant defense. Nucleic Acids Research, 2018, 46 (7), 3595-3611. (IF2020: 16.971)
4.Weihui Li and Zheng-Guo He*. LtmA, a novel cyclic di-GMP-responsive activator,broadly regulates the expression of lipid transport and metabolism genes in Mycobacterium smegmatis. Nucleic Acids Research, 2012, 40 (22), 11292-11307. (IF2020: 16.971)
5.Qingbin Hu, Jiaxun Zhang, Yu Chen, Lihua Hu, Weihui Li*, Zheng-Guo He*. Cyclic di-GMP co-activates the two-component transcriptional regulator DevR in Mycobacterium smegmatis in response to oxidative stress. Journal of Biological Chemistry, 2019, 294(34), 12729-12742. (共同通讯作者)
6.Liang Zhou, Zheng-Guo He and Weihui Li*. AraR, a L-arabinose-responding transcription factor, negatively regulates the isoniazid resistance of M. smegmatis. Biochemistry (Moscow), 2019, 84 (5), 540-552. (通讯作者)
7.Yugang Li, Weihui Li, Zhiwei Xie, Hui Xu, Zheng-Guo He*. MpbR, an essential transcriptional factor for Mycobacterium tuberculosis survival in the host, modulates PIM biosynthesis and reduces innate immune responses. Journal of Genetics and Genomics, 2019, 46, 575-589.
8.Yu Liu#, Zhiwei Xie#, Xiling Zhou, Weihui Li, Hua Zhang* and Zheng-Guo He*. NapM enhances the survival of Mycobacterium tuberculosis under stress and in macrophages. Communications Biology, 2019, 2: 65.
9.Feng Huang, Weihui Li, Hui Xu, Huafeng Qin, Zheng-Guo He*. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase. PLoS One, 2019, 14(6): e0218449.
10.Jialing Hu, Hua Zhang, Si Zhou, Weihui Li and Zheng-Guo He*. Characterization of a novel regulatory pathway for the mannitol metabolism and its coordination with the biofilm formation in Mycobacterium smegmatis. Journal of Genetics and Genomics, 2018, 45 (9), 477-488.
11.Tao Cui, Weihui Li, Lei Liu, Qiaoyun Huang and Zheng-Guo He*. Uncovering New Pathogen-Host Protein-Protein Interactions by Pairwise Structure Similarity. PLoS One, 2016, 11(1): e0147612.
12.Haiwei Zhang, Long Gao, Jiaoling Zhang, Weihui Li, Min Yang, Hua Zhang, Chunhui Gao and Zheng-Guo He*. A Novel marRAB Operon Contributes to the Rifampicin Resistance in Mycobacterium smegmatis. PLoS One, 2014, 9 (8): e106016.
13.Lei Zhang, Weihui Li and Zheng-Guo He*. DarR, a TetR-like Transcriptional Factor, Is Cyclic Di-AMP-responsive Repressor in Mycobacterium smegmatis. Journal of Biological Chemistry, 2013, 288 (5), 3085-3096.
14.Yi Wang#, Tao Cui#, Cong Zhang, Min Yang, Yuanxia Huang, Weihui Li, Lei Zhang, Chunhui Gao, Yang He, Yuqing Li, Feng Huang, Jumei Zeng, Cheng Huang, Qiong Yang, Yuxi Tian, Chunchao Zhao, Huanchun Chen, Hua Zhang and Zheng-Guo He*. A Global Protein-protein Interaction Network in the Human Pathogen Mycobacterium tuberculosis H37Rv. Journal of Proteome Research, 2010, 9 (12), 6665-6677.
15.Hui Xu, Zhi Su, Weihui Li, Yimin Deng and Zheng-Guo He*. MmbR, a master transcription regulator that controls fatty acid β-oxidation genes in Mycolicibacterium smegmatis. Environmental Microbiology, 2021, 23(2): 1096-1114.
16.Xiaohui Li, Liu Chen, Jingjing Liao, Jiechen Hui, Weihui Li and Zheng-Guo He*. A novel stress-inducible CmtR-ESX3-Zn2+ regulatory pathway essential for survival of Mycobacterium bovis under oxidative stress. Journal of Biological Chemistry, 2020, 295 (50),17083-17099.